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Analysis of Complex Diseases: A Mathematical Perspective

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Guanyu Wang PhD, "Analysis of Complex Diseases: A Mathematical Perspective"
English | ISBN: 1466572213 | 2014 | 222 pages | PDF | 5 MB

Analysis of Complex Diseases: A Mathematical Perspective
A complex disease involves many etiological and risk factors operating at multiple levels-molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize treatments. The understanding of biological data derived from studying diseases can be enhanced by theories and mathematical models, which clarify the big picture and help to reveal the overarching mechanisms that govern complex biological phenomena.

Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, Analysis of Complex Diseases: A Mathematical Perspective presents a holistic approach for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. Using mathematics to identify patterns of deviation from normality, or the healthy state-spanning multiple levels from molecules to the organism-the author identifies a range of dynamical behaviors that correspond to either cellular physiology or pathology. He uses the information from multiple levels in order to develop a unified theory, which includes the discovery that certain diseases may stem from well-evolved, useful mechanisms activated in the wrong context.

This book is divided into three parts. Part I focuses on the organismal level to describe normal physiology and how the body as a whole meets its functional requirements. Part II addresses the subcellular, molecular level to elucidate the organizing principles of cellular biomolecules to meet the demands of the organism. Part III examines complex diseases by combining information from the organismal level and the molecular level, offering a paradigm that can be extended to the study of other categories of diseases.
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Handbook of International Human Resource Management: Integrating People, Process, and Context

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Handbook of International Human Resource Management: Integrating People, Process, and Context by Paul Sparrow

English | 2009 | ISBN: 1405167408 | ISBN-13: 9781405167406 | 540 pages | PDF | 4 MB

From the mid-1980s to the turn of the 1990s the international HR field was considered to be in its infancy. There continues to be both an evolution of territory covered by the field – a series of successively evolving cultural, geographical and institutional challenges faced by the multinational corporation (MNC) – as well as more critical questioning whether this has created an expanded or a fragmented field.

Handbook of International Human Resource Management: Integrating People, Process, and Context
This book brings together the latest research on important "issues-driven" concerns that the field of IHRM now has to face, absorb, interpret then reanalyse through international lenses. This volume gives attention to those aspects of MNC behaviour – choices about location, how they organize local subsidiaries, choices made about technology, capital and labour, and choices made about investments and strategies – that are subject to institutional influences. It also gives voice to a number of contemporary issues – reverse knowledge flows, skill supply strategies, employer branding, e-enablement, outsourcing, global networks – that now need to be accommodated within the field.

' Broadens the IHRM field to cover comparative and institutional perspectives
' Provides a multi-level analysis of globalization phenomena at the individual, organization, and macro level
' Focuses on the current problems and issues driving the attention of IHRM Directors
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